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BAY 11-7082 (E)-3-[(4-methylphenylsulfonyl]-2- propenenitrile
Catalog No: KC-4B001 Size: 10 mg |
Physical Appearance: Off-white solid (m.p. 128-130°C)
Molecular Formula: C10H9NO2S
Molecular Weight: 207.3
Purity: 99%
Solubility: Soluble in DMSO (>25 mg/ml) and ethanol (15 mg/ml)
Storage: Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Description: An irreversible inhibitor of cytokine-inducible IκBα phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα without affecting constitutive phosphorylation. Inhibition of IκBα phosphorylation and degradation results in the inactivation of NF-κB and NF-κB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1.
References:
1. J.W. Pierce et al. J. Biol. Chem. 1997 272 21096
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.