Rabbit Anti-MESDC2/FITC Conjugated antibody

FITC标记的中胚层分化蛋白2抗体

英文名称Anti-MESDC2/FITC中文名称FITC标记的中胚层分化蛋白2抗体别    名BOCA; KIAA0081; LDLR chaperone MESD; MESD; MESD_HUMAN; MESDC 2; mesdc2; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY REN 61; Renal carcinoma antigen NY-REN-61.  规格价格100ul/2980元 购买        大包装/询价说 明 书100ul  研究领域细胞生物  发育生物学  干细胞  细胞分化  抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Cow, Horse, Sheep, 产品应用ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量23kDa性    状Lyophilized or Liquid浓    度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human MESDC2亚    型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background:
MESDC2 is a 234 amino acid endoplasmic reticulum protein belonging to the MESD family. Considered a chaperone protein, MESDC2 specifically assists in folding beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) through N- and C-terminal unstructured regions. MESDC2 modulates the Wnt pathway by chaperoning coreceptors LRP5 and LRP6 to the plasma membrane, and is essential for mesoderm induction and embryonic polarity. The gene encoding MESDC2 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Function:
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.

Subunit:
Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane.

Subcellular Location:
Endoplasmic reticulum.

Similarity:
Belongs to the MESD family.

Database links:

Entrez Gene: 23184 Human

Omim: 607783 Human

SwissProt: Q14696 Human

Unigene: 578450 Human

Unigene: 732380 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MESDC2是属于MESD家族的234氨基酸内质网蛋白。作为伴侣蛋白，MESDC2通过N-端和C-端非结构区特异性地帮助折叠低密度脂蛋白受体(LDLR)家族中的β-螺旋桨/EGF模块。MESDC2通过伴随共受体LRP5和LRP6到质膜来调节Wnt通路，对于中胚层诱导和胚胎极性是必不可少的。编码MESDC2的基因映射到人类15号染色体上，该基因包含700个以上的基因，并包含人类基因组的近3%。Angelman综合征、Prader-Willi综合征、Tay-Sachs病和Marfan综合征均与染色体15定位基因缺陷有关。