FITC标记的脑磺基转移酶样蛋白4A1抗体
产品名称： FITC标记的脑磺基转移酶样蛋白4A1抗体
英文名称： Anti-SULT4A1/FITC
产品编号： HZ-11763R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SULT4A1/FITC Conjugated antibody
FITC标记的脑磺基转移酶样蛋白4A1抗体
| 产品编号 | bs-11763R-FITC |
| 英文名称 | Anti-SULT4A1/FITC |
| 中文名称 | FITC标记的脑磺基转移酶样蛋白4A1抗体 |
| 别 名 | BR STL 1; Brain sulfotransferase like protein; Brain sulphotransferase like; BRSTL1; hBR STL 1; hBR STL; Nervous system cytosolic sulfotransferase; Nervous system sulfotransferase; NST; Sulfotransferase 4A1; Sulfotransferase family 4A member 1; Sulfotransferase related protein; SULTX3; ST4A1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SULT4A1 (221-284aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Sulfation is an essential conjugation reaction that increases the water solubility of many compounds, thereby influencing their renal excretion and also resulting in the formation of active metabolites. SULT4A1 (sulfotransferase family 4A, member 1), whose alternative names include brain sulfotransferase-like protein, nervous system sulfotransferase, NST, SULTX3, hBR-STL-1, BRSTL1, BR-STL-1, MGC40032 and DJ388M5.3, is a 284 amino acid protein showing cytoplasmic localization. As a member of the sulfotransferase 1 family, SULT4A1 plays a role in elimination of xenobiotics, activation of procarcinogens and regulation of hormones. SULT4A1 is highly expressed in cerebral cortex and frontal lobe, with lower expression in cerebellum, temporal and occipital lobes. Two SULT4A1 isoforms exist to alternative splicing events. The gene encoding SULT4A1 maps to human chromosome 22q13.2, a region which has been implicated in predisposition to schizophrenia. Function: SULT4A1 is a member of the sulfotransferase family. It is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. It may catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. There are two named isoforms. Subcellular Location: Cytoplasmic Tissue Specificity: Highly expressed in the cerebral cortex andfrontal lobe, slightly less in the cerebellum, occipital andtemporal lobes, relatively low in the medulla and putamen, andlowest in the spinal cord. No expression detected in the pancreas(PubMed:10698717). Highly expressed in fetal brain and occipitallobe, slightly less in the whole brain, frontal lobe, hippocampus,and lung, very low expression in cerebellum, medulla oblongata,temporal lobe, testis, kidney and appendix (PubMed:12039030). Similarity: Belongs to the sulfotransferase 1 family. Database links: Entrez Gene: 618738 Cow Entrez Gene: 25830 Human Entrez Gene: 29859 Mouse Entrez Gene: 100009444 Rabbit Entrez Gene: 58953 Rat Omim: 608359 Human SwissProt: Q9BR01 Human SwissProt: P63046 Mouse SwissProt: P63047 Rat Unigene: 189810 Human Unigene: 248796 Mouse Unigene: 162965 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
硫酸化是一个重要的共轭反应，增加许多化合物的水溶性，从而影响它们的肾脏排泄，也导致活性代谢物的形成。Sult4A1（磺基转移酶家族4A，成员1），其选择性名称包括脑磺基转移酶样蛋白、神经系统磺基转移酶、NST、SULTX3、HBRSTL-1、BRSTL1、BR-SST-1、MGC400 32和DJ38 8M5.3，是显示胞质定位的284氨基酸蛋白。作为磺基转移酶1家族成员，SULT4A1在外源性物质的消除、致癌原的激活和激素的调节中起着重要的作用。SULT4A1在大脑皮质和额叶中高表达，在小脑、颞叶和枕叶中表达较低。两个SULT4A1亚型存在选择性剪接事件。编码SULT4A1的基因定位于人类染色体22q132，该区域与精神分裂症的倾向有关。